Substituted 4'-hydroxyphenylacetic acid derivatives having antii

Details Substituted 4'-hydroxyphenylacetic acid derivatives having antii Substituted 4'-hydroxyphenylacetic acid derivatives having antii

1989-03-22

1993-06-15

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564158, 548253, 554 51, 554116, C07C23304

Patent

active

052200647

ABSTRACT:
The present invention is novel compounds, which are derivatives of 4'-hydroxyphenylacetic acid having antiinflammatory activity for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, and having analgesic activity. Particularly, the analgesia may be useful for the treatment of dental pain and headache, especially vascular headache, such as migraine, cluster and mixed vascular syndromes, as well as nonvascular tension headache.

REFERENCES:
patent: 3268582 (1966-08-01), Zelle et al.
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patent: 4448730 (1984-05-01), Van't Riet et al.
patent: 4579866 (1986-04-01), Stevenson et al.
Ott et al, Liedigs Ann., 425, pp. 314-337 (1921).
Szolesanyi et al, Arzneim.-Forsch, 25, No. 12 pp. 1877-1881 (1975).

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