Substituted 4-hydroxy-isophthalic acid picolylamides having a ph

Details Substituted 4-hydroxy-isophthalic acid picolylamides having a ph Substituted 4-hydroxy-isophthalic acid picolylamides having a ph

1978-08-29

1981-10-13

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424266, 546265, 546267, A61K 3144, C07D21340

Patent

active

042948339

ABSTRACT:
There are prepared 4-hydroxy-isophthalic acid bis (3- or 4-picolyl-amides) of the formula (I) ##STR1## where R' is H or an aliphatic or alicyclic hydrocarbon group with 1 to 16 carbon atoms, R'''' is 3-pyridyl or 4-pyridyl, R''' is H, Cl, NO.sub.2, or --OCH.sub.3, R'' is an aliphatic or alicyclic hydrocarbon group with 1 to 8 carbon atoms with the exception that when R'''' is 3-pyridyl and R' and R''' are both H, then R'' is an aliphatic or alicyclic hydrocarbon radical with 3 to 8 carbon atoms. The compounds are useful in inhibition of blood platelet aggregation.

REFERENCES:
patent: 3923820 (1975-12-01), Roldan et al.
patent: 3973026 (1976-08-01), Orzalesi et al.

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