Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matr

Details Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matr Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matr

1997-10-30

1999-08-17

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

514417, 514532, 514543, 514278, 548479, A61K 31405, A61K 3140, C07D20708, C07D20948

Patent

active

059395834

ABSTRACT:
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## in which T is a pharmaceutically-acceptable substituent group; A is CH.sub.2, CH, or N; G is CH.sub.2 or CH; and R.sup.1 is any of a variety of disclosed substituent groups. The class of compounds of the invention includes ring-containing materials in which the units A and G are joined. The compounds of the invention are mixtures of diastereomers, or individual diastereomers making up these mixtures.

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Chem. Abstr. 120: 322938r (1994); Kuchar, Grimova, and Maturova, 4-(2,4-Difluorobiphenylyl)-4-hydroxy-2-methyl-butanoic acid and lactone, useful as antiinflammatories. Czech. CS 276,834.

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