Substituted 4-biarylbutyric acid derivatives as matrix metallopr

Details Substituted 4-biarylbutyric acid derivatives as matrix metallopr Substituted 4-biarylbutyric acid derivatives as matrix metallopr

1997-05-30

1999-03-23

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514545, 514423, 514616, 562459, 560 51, 548536, 548537, 564155, 564158, A61K 3119, A61K 31235, C07C 5974, C07C 6776

Patent

active

058860436

ABSTRACT:
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the group R6 represents variety of possible substituent groups on the carbon chain between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12, and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.

REFERENCES:
patent: 3182061 (1965-05-01), Goldschmidt
patent: 3624142 (1971-11-01), Shen et al.
patent: 3652646 (1972-03-01), Leigh et al.
patent: 3707549 (1972-12-01), Mills
patent: 3749750 (1973-07-01), Wei
patent: 3754021 (1973-08-01), Shen et al.
patent: 3784701 (1974-01-01), Tomcufcik et al.
patent: 3867434 (1975-02-01), Diamond
patent: 3876800 (1975-04-01), Krausz et al.
patent: 3882174 (1975-05-01), Seeger et al.
patent: 3917846 (1975-11-01), Diamond et al.
patent: 3962228 (1976-06-01), Wei et al.
patent: 3993683 (1976-11-01), Nickl et al.
patent: 3997589 (1976-12-01), Seeger et al.
patent: 4008323 (1977-02-01), Cousse et al.
patent: 4021479 (1977-05-01), Seeger et al.
patent: 4049823 (1977-09-01), Schacht et al.
patent: 4058558 (1977-11-01), Cousse et al.
patent: 4151302 (1979-04-01), Gante et al.
patent: 4168385 (1979-09-01), Trust et al.
patent: 4219668 (1980-08-01), Chiccarelli
patent: 4247466 (1981-01-01), Chiccarelli
patent: 4271191 (1981-06-01), Mazoyer
patent: 4304788 (1981-12-01), Edge
patent: 4310544 (1982-01-01), Edge
patent: 4472316 (1984-09-01), Sota et al.
patent: 4577025 (1986-03-01), Arai et al.
patent: 4594197 (1986-06-01), Tomisawa et al.
patent: 4683331 (1987-07-01), Kuchar et al.
patent: 4933367 (1990-06-01), Wolff et al.
patent: 4937243 (1990-06-01), Markwell et al.
patent: 5098613 (1992-03-01), Bollinger et al.
patent: 5109000 (1992-04-01), Markwell et al.
patent: 5124322 (1992-06-01), Hughes
patent: 5177204 (1993-01-01), Kuchar et al.
patent: 5462954 (1995-10-01), Baker et al.
patent: 5473100 (1995-12-01), Isomura et al.
patent: 5525629 (1996-06-01), Crimmin et al.
patent: 5591891 (1997-01-01), Fournie-Zaluski et al.
Chiccarelli et al., "Disposition and Metabolism of Fenbufen in several Laboratory Animals", Arzneim.-Forsch./Drug Res., 30(I), 707-715 (1980).
Child et al., "A New Non-steroidal Anti-inflammatory Analgesic: .gamma.-Oxo (1,1'-biphenyl)-4-butanoic Acid (Fenbufen)", Arzneim.-Forsch./Drug Res., 30(I), 695-702 (1980).
Child et al., "Fenbufen, a New Anti-Imflammatory Analgesic: Synthesis and Structure-Activity Relationships of Analogs", J. Pharma. Sci., 66(4), 466-476 (1977).
Cousse et al., "Synthese, structure et activite hypocholesterolemiante d'une serie d'acides .gamma.-aryl, .gamma.-oxo butyriques substitues et derives", Eur. J. Med. Chem., 22, 45-57 (1987).
Curran, W. V. and Ross, A., "6-Phenyl-4,5-dihydro-3(2H)-pyridazinones. A Series of Hypotensive Agents", J. Med. Chem., 17(3), 273-281 (1974).
Farbenind, I.G., "Compounds having capillary actions", Chem. Abstracts, 30, 7729.sup.3 (1936).
Kameo et al., "Studies on Antirheumatic Agents: 3-Benzoylpropionic Acid Derivatives", Chem. Pharm. Bull., 36(6), 2050-2060 (19880.
Kawashima et al., "Structure-Activity Studies of 3-Benzoylpropionic Acid Derivatives Suppressing Adjuvant Arthritis", Chem. Pharm,. Bull., 40(3), 774-777 (1992).
Tomisawa et al., "Studies on Hypolipidemic Agents. II. 3-(4-Phenoxybenzoyl)-propionic Acid Derivatives", Chem. Pharm. Bull., 33(6), 2386-2394 (1985).
Weizmann et al., "A New Method for the Synthesis of .beta.-Phenyl-Naphthalene Derivatives", Chemistry and Industry, pp. 402-404, Jun. 8, 1940.
Sammour et al., "Alkylation of Aromatic Hydrocarbons with .beta.-Aroylacrylic Acids", J. Prakt. Chemie, 314, 5-6, 906-914 (1972).
El-Hashash et al., "Reactions of 3,5-Disubstituted-2-Furanone with Amines, Grignard Reagents, Toluene and Xylene", Indian Journal of Heterocyclic Chemistry, 5, 231-232 (1996). benzoyl! propionic Acids Derivatives", Chem.Pharm. Bull., 37(5), 1260-1267 (1989).
Takeshita et al., "Immunopharmacological Studies of New 3-Benzoyl-4-Mercaptobutyric Acid Derivatives. II Immunosuppressive Effects", Drug Exptl.Clin.Res., XIV(5), 311-318 (1988).
Fournel et al., "Differential induction profile of drug-metabolizing enzimes after treatment with hypolipidemic agents", Xenobiotica, 17(4), 445-457 (1987).
Kuchar t al., "Quantitative Relations Between Structure and Anti Inflammatory Activity of Ayloxoalkanoic Acids", Collection Czechoslovak Chem.Commun., 53, 1862-1872 (1988).
Chem.Abstr. Accession No. 108: 31304. Kuchar, et al., Metabolic Model and QSAR of Long-acting Anti-inflammatory Arylaliphatic Acids, 1985.

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