Substituted 4-biarylbutyric acid derivatives as matrix metallopr

Details Substituted 4-biarylbutyric acid derivatives as matrix metallopr Substituted 4-biarylbutyric acid derivatives as matrix metallopr

1997-05-30

1999-01-19

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514571, 514350, 514312, 514423, 514539, 514616, 549 62, 562463, 546299, 546156, 548533, 548537, 560 9, 560 17, 560 35, 560 39, A61K 3138, A61K 3119, A61K 3144, A61K 3124

Patent

active

058614281

ABSTRACT:
Inhibitors for matrix metalloproteases, pharmaueutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each Tis a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the group R6 reresents a variety of possible substituent groups on the carbon chain between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12, and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.

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