Substituted 4-benzylpiperazinyl compounds

Details Substituted 4-benzylpiperazinyl compounds Substituted 4-benzylpiperazinyl compounds

1989-01-11

1990-04-17

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540458, 540459, A61K 31395, C07D52100

Patent

active

049180665

ABSTRACT:
3-W-Rifamycin SV and S compound, wherein W is a piperazin-1-yl radical of the formula ##STR1## wherein R.sup.1 and R.sup.2 are C.sub.1 -C.sub.4 alkyl and R.sup.3, R.sup.4 and R.sup.5 are hydrogen or C.sub.1 -C.sub.4 alkyl, or R.sup.2 together with R.sup.3 or R.sup.3 together with R.sup.4 are buta-1,3-dien-1,4-ylene, trimethylene or tetramethylene, each of which is unsubstituted or substituted by C.sub.1 -C.sub.4 alkyl, and R.sup.1, R.sup.4 and R.sup.5 or R.sup.1, R.sup.2 and R.sup.5 are hydrogen or C.sub.1 -C.sub.4 alkyl, and salts thereof, have long-term antituberculotic and antimicrobial activity.

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CA 107: 108862z (1987).
Chemical Abstracts vol. 108, (1988) Item 150,158, abstracting South African Patent ZA 85 08 167, Jun. 24, 1987.

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