Substituted 4-anilinoquinazolines and their use in tumor...

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

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C546S199000

Reexamination Certificate

active

07825245

ABSTRACT:
The present invention relates to quinazoline derivatives of formula I:wherein X, Y, Z, R1, R2, R3, and R4are as defined herein. The invention also relates to a method of preparing these compounds, and use of these compounds for inhibiting tumor growth.

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Jordan, V. C. Nature Reviews: Drug Discovery, 2, 2003, 205.
Dörwald, F. Zaragoza. Side Reactions in Organic Synthesis: A Guide to Successful Synthesis Design, Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA, 2005, Preface.

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