Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhib

Details Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhib Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhib

1998-03-17

1999-12-14

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544280, C07D48704, A61K 31505

Patent

active

060018399

ABSTRACT:
Compounds of formula I ##STR1## including pharmaceutically acceptable salts thereof in which R.sub.1 represents hydrogen, 2-phenyl-1,3-dioxan-5-yl, a C.sub.1-6 alkyl group, a C.sub.3-8 cycloalkyl group, a C.sub.5-7 cycloalkenyl group or an (optionally substituted phenyl)C.sub.1-6 alkyl group wherein the alkyl, cycloalkyl and cycloalkenyl groups are optionally substituted by one or more groups of formula OR.sub.A in which R.sub.A represents H or a C.sub.1-6 alkyl group provided that a group of formula OR.sub.A is not located on the carbon attached to nitrogen;

REFERENCES:
patent: 5593997 (1997-01-01), Dow et al.
patent: 5639757 (1997-06-01), Dow et al.
patent: 5665721 (1997-09-01), Bhagwat et al.
patent: 5834469 (1998-11-01), Elliott et al.
Hanke, J.H., et al. "Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor; Study of Lck-and FynT-dependent T Cell Activation". J Biol Chem. 271(2):695-701, 1996.

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