Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their...

Details Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their... Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their...

2006-11-21

2006-11-21

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S228200, C514S234500, C544S061000, C544S116000, C544S253000

Reexamination Certificate

active

07138398

ABSTRACT:
The present invention relates to compounds of formula (I) wherein R1, R2and R3have the meanings given in the claims. Said compounds are valuable active agents in medicaments for the treatment and prophylaxis of diseases, for example cardiovascular diseases such as hypertension, angina pectoris, heart failure, thrombosis and atherosclerosis. The compounds of formula (I) are able to modulate the body's own production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the treatment and prophylaxis ofisorders associated with an impaired cGMP balance. The invention also relates to methods for producing compounds of formula (I), to their use in the treatment and prophylaxis of the above diseases and in the preparation of medicaments for such diseases, and to pharmaceutical preparations containing the compounds of formula (I).

REFERENCES:
patent: 6627628 (2003-09-01), Schindler et al.
Carvajal et al., Molecular Mechanism of cGMP-mediated Smooth Muscle Relaxation, Journal of Cellular Physiology, 184:409-420, 2000.
Yamashita et al., Mechanisms of Reduced Nitric Oxide/cGMP-mediated Vasorelaxation in Transgenic Mice Overexpressing Endothelial Nitric Oxide Synthase, Hypertension, 36:97-102, 2000.
Wolin et al., Review: Oxidant-13 Nitric Oxide Signalling Mechanisms in Vascular Tissue, Biochemistry, vol. 63, No. 7, pp. 958-965, 1998.
Prandoni, The Treatment of venous thromboembolic disorders: new challenges and opportunities, Haematological/Journal of Haematology, 88(05):610-613, May 2003.
Lerman, Women and Ischemia Syndrome Evaluation (WISE) Diagnosis and Pathophysiology of Ischemic Heart Disease Workshop, Oct. 2002.
Koren, Diastolic Congestive Heart Failure, Jacksonville Medicine, Feb. 2002.
Ko et al., YC-1, a Novel Activator of Platelet Guanylate Cyclase, Blood, vol. 84, No. 12, pp. 4226-4233, Dec. 15, 1994.
Adnot et al., PubMed Abstract (Arch Mal Coeur Vaiss. 87 Spec No. 4:41-51) Dec. 1994.
Ayajiki et al., PubMed Abstract (Nippon Yakurigaku Zasshi, 119(1):21-8), Jan. 2002.

Affiliated with

Also associated with

Rating

Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3693706