Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinon

Details Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinon Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinon

1983-03-22

1988-03-29

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514252, 544238, 544239, C07D23704, A61K 3150

Patent

active

047344156

ABSTRACT:
Substituted 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinone compounds and 6-(substituted)phenyl-3(2H)-pyridazinone compounds and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents.
Said compounds cause a significant increase in myocardial contractility in the dog. Said compounds also cause a decrease in blood pressure in the spontaneously hypertensive rat. Said compounds are produced by reacting substituted .gamma.-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinones which are dehydrogenated to 6-(substituted)phenyl-3(2H)-pyridazinones.
Both the intermediate 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinones and the 6-(substituted)phenyl-3(2H)-pyridazinones are useful as cardiotonic and antihypertensive agents.

REFERENCES:
patent: 3975388 (1976-08-01), Hakim et al.
patent: 4353905 (1982-10-01), Sircar et al.
patent: 4361563 (1982-11-01), Austel et al.
patent: 4397854 (1983-08-01), Sircar
patent: 4507298 (1985-03-01), Lautenschlager
patent: 4521415 (1985-06-01), Katakami et al.
patent: 4551455 (1985-11-01), Hilboll et al.

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