Substituted 3-thia- and 3-oxa-alkylflavones, a process for their

Details Substituted 3-thia- and 3-oxa-alkylflavones, a process for their Substituted 3-thia- and 3-oxa-alkylflavones, a process for their

1991-04-04

1992-12-22

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549403, A61K 3135, C07D31130

Patent

active

051734982

ABSTRACT:
Substituted 3-thia- and 3-oxa-alkylflavones of formula I ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 X, m and n have the indicated meanings, a process for the preparation of these compounds and their use as medicaments and pharmaceutical preparations are described. In addition, new intermediates for the preparation of the compounds of formula I are described.

REFERENCES:
patent: 3462455 (1969-08-01), Kramer et al.
patent: 4591600 (1986-05-01), Creuzet et al.
patent: 4713465 (1987-12-01), Kramer et al.
patent: 4788215 (1988-11-01), Kramer et al.
patent: 4925852 (1990-05-01), Kesseler et al.
Beck et al., Tetrahedron Lett., 1990, 31(50), 7293-6. (CA 114:101,427x, 1991).
Monty Krieger et al., "Replacement of Neutral Lipids of Low Density Lipoprotein with Esters of Long Chain Unsaturated Fatty Acids", The Journal of Biological Chemistry, vol. 254, No. 10, Issue of May 25, pp. 3845-3853, 1979.
Hermann Esterbauer et al., "Autoxidation of Human Low Density Lipoprotein Loss of Polyunsaturated Fatty Acids and Vitamin E and Generation of Aldehydes", Journal of Lipid Research, vol. 28, 1987, pp. 495-508.
Toru Kita et al., "Probucol Prevents the Progression of Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbit, an Animal Model for Familial Hypercholesterolemia", Proc. Natl. Acad. Sci. USA, vol. 84, pp. 5928-5931, Aug. 1987.
Wulf Palinski et al., "Low Density Lipoprotein Undergoes Oxidative Modification in Vivo", Proc. Natl. Acad. Sci. USA, vol. 86, pp. 1372-1376, Feb. 1989.

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