Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2003-11-14
2009-12-01
Desai, Rita J. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S320000
Reexamination Certificate
active
07626031
ABSTRACT:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
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Cheng Wei
Co Erick Wang
Kim Moon Hwan
Klein Rhett Ronald
Le Donna Tra
Desai Rita J.
Mabry John
McDonnell Boehnen & Hulbert & Berghoff LLP
Symphony Evolution, Inc.
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