Substituted-(3-cyclopentyloxy-4-methox yphenyl)-3-phenylcyanocyc

Details Substituted-(3-cyclopentyloxy-4-methox yphenyl)-3-phenylcyanocyc Substituted-(3-cyclopentyloxy-4-methox yphenyl)-3-phenylcyanocyc

1999-04-08

2000-09-12

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

560 35, 560 51, 560 55, 564271, 568306, 568329, 568330, 514520, 514523, 514532, 514541, 514641, 514676, 514683, 514684, C07C25500, C07C22900, C07C24900, C07C20500, C07C 4923

Patent

active

061180173

ABSTRACT:
This invention relates to ketones, alcohols and amines and acids represented by the likes of 3-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylcyanoclobutan-1-one. They are useful as PDE 4 antngionists.

REFERENCES:
patent: 5187192 (1993-02-01), Brooks et al.
patent: 5362915 (1994-11-01), Maschler et al.
patent: 5552438 (1996-09-01), Christensen
patent: 5712298 (1998-01-01), Amschler
patent: 5883106 (1999-03-01), Stevens et al.
Honda et al, "Chiral synthesis of phosphodiesterase inhibitor rolipram . . .", CA 124:260749, 1996.
Honda, et al., "Chiral synthesis of phosphodiesterase inhibitor, .RTM.-(-)-rolipra, by means of enantioselective deprotonation strategy". Heterocycles, Jan. 1996, vol. 42, No. 1, pp. 109-111, especialy p. 10.

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