Substituted 3-cyano quinolines

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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Details

514313, 546156, 546157, 546159, 546160, 546161, A01A 4342, C07D21516, C07D21538

Patent

active

060020083

ABSTRACT:
This invention provides compounds having the formula: ##STR1## wherein: X is cycloalkyl which may be optionally substituted; or is a pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally substituted;

REFERENCES:
patent: 5480883 (1996-01-01), Spada et al.
patent: 5686457 (1997-11-01), Traxler et al.
Bridges A. J. et al., Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure--Activity Relationship for Analogues of 4-(3-Bromoamiline)-6,7-dimethoxyquinazoline. (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor, J. Med. Chem., 1996, 39, 267-276.
Dolle R. E. et al., 5,7-Dimethoxy-3-(4-pyridinyl)quinoline Is a Potent and Selective Inhibitor of Human Vascular .beta.-Type Platelet-Derived Growth factor Receptor Tyrosine Kinase, J. Med. Chem., 1994, 37, 2627-2629.
Ife, R. J. et al., Reversible Inhibitors of the Gastric (H.sup.+ /K.sup.+)-ATPase. 3.3-Substituted-4-(phenylamine)quinolines, J. Med. Chem., 1992, 35, 3413-3422.
Maguire M. P. et al., A New Series of PDGF Receptor Tyrosine Kinase Inhibitors: 3-Substituted Quinoline Derivatives, J. Med. Chem., 1994, 37, 2129-2137.
Rewcastle G. W. et al., Tyrosine Kinase Inhibitors. 5. Synthesis and Structure-Activity Relationships for 4-[( Phenylmethyl)amino]-and 4-(Phenylamino) quinazolines as Potent Adenosine 5'-Triphosphate Binding Site Inhibitors of the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor, J. Med. Chem,. 1995, 38, 3482-3487.
Fry, D. W. et al., A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, Science, 265, 1994, 1093-1095.
Gazit A. et al., Tyrphostins. 5. Potent Inhibitors of Platelet-Derived Growth Factor Receptor Tyrosine Kinase: Structure-Activity Relationships in Quinoxalines, Quinolines, and Indole Tyrpostins, J. Med. Chem., 1996, 39, 2170-2177.
Price, C. C. et al., J. Amer. Chem. Soc., vol. 68, (1946) pp. 1246-1250.

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