Substituted 3-amino chromans

Details Substituted 3-amino chromans Substituted 3-amino chromans

1992-12-21

1994-04-26

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31158

Patent

active

053068300

ABSTRACT:
The present invention is directed to novel chromane derivatives substituted in the 3-position by a substituted amino moiety and substituted on the aromatic ring with one or two substituents. The novel chromane derivatives have useful CNS properties. ##STR1##

REFERENCES:
patent: 4801605 (1989-01-01), Hutchison
Sarda, N. et al.--Chemical Abstract 85:153938s, "Pharmacological and biochemical study of 3-aminochromans;" (1976).
Sarda, N. et al.--Chemical Abstracts 86:5270y, "Syntheses and conformations of 3-aminochromans," (1977).
Sarda, N. et al.--Chemical Abstract 82:31208w, "Synthesis and stereochemistry of 3-amino-4-chromanols and 3-aminochromans," (1975).
Sarda, N. et al.--Chemical Abstract 92:52486g, "Effects of 3-amino chroman derivatives on the synthesis index, the capture and spontaneous efflux on catecholamines and serotonin in different regions of the rate brain," (1980).
Cossery, J. M. et al.--Chemical Abstract 107:190822t, "The selective labelling of central 5HT.sub.1A receptor binding sites by [.sup.3 H]5-methoxy-d--(di-n-propylamino)chroman," (1987).

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