Substituted 3,4-dihydronaphthalenes, pharmaceutical compositions

Details Substituted 3,4-dihydronaphthalenes, pharmaceutical compositions Substituted 3,4-dihydronaphthalenes, pharmaceutical compositions

1992-07-10

1993-10-19

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Hydroxamic acids, chalcogen analogs or salts thereof

562623, 514507, C07C 5306

Patent

active

052547310

ABSTRACT:
Substituted 3,4-dihydronaphthalenes of the formula I ##STR1## wherein R.sup.1 is a methyl or an amino group, R.sup.2 represents a hydrogen atom or a methyl group, and R.sup.3 is a linear or branched chain alkyl residue having 1 to 4 carbon atoms, an allyl or a crotyl group or a cyclopentyl group are disclosed which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of disorders attributable to the action of leucotrienes. The dihydronaphthalenes may be prepared by reacting a compound of formula II ##STR2## with hydroxylamine or a salt thereof to form the corresponding oxime, reducing the oxime to a hydroxylamine of formula III ##STR3## and introducing a --CO--R.sup.1 group.

REFERENCES:
Jakschik et al., Biochem. Biophys. Res. Commun., 102, 624 (1981).
Tateson et al., in Brit. J. Pharmacol., 94, 528 (1988).
J. B. Summers et al., J. Med. Chem., 31, 1960 (1988).

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