Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-05-24
2011-05-24
Moore, Susanna (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S346000
Reexamination Certificate
active
07947682
ABSTRACT:
Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Such compounds include a compound of Formula II,whereinR is H, alkyl, or halogen;R′ is H, alkyl, or halogen;X is CH or N; andY comprises a homocyclic or heterocyclic ring.Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating gene expression.
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Garofalo Antonio
Neamati Nouri
DLA Piper (LLP) US
Moore Susanna
University of Southern California
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