Substituted 2H,3H-2,1-benzisothiazole-S-oxides, method of use an

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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260304A, C07D27506

Patent

active

040312275

ABSTRACT:
The invention discloses substituted 2H,3H-2,1-benzisothiazole-S-oxides having pharmacological activity in animals and useful as CNS depressant agents. The compounds may be prepared by reacting a substituted 2H,3H-2,1-benzisothiazole with an oxidizing agent. The substituted 2H,3H-2,1-benzisothiazole may be prepared by reacting a substituted .alpha.-methylthio-o-toluidine with one equivalent of an oxidizing agent, followed by treatment with base.

REFERENCES:
williams et al., J. Am. Chem. Soc., 93 (26), 12-1971.

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