Substituted 2-pyrrolidinone activators of PKC

Details Substituted 2-pyrrolidinone activators of PKC Substituted 2-pyrrolidinone activators of PKC

1998-09-08

1999-10-05

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548217, 548407, 548546, 548547, A61K 3140, C07D20726

Patent

active

059625040

ABSTRACT:
Compounds of formula I: ##STR1## wherein R.sub.1 and R.sub.2 have any of the values defined in the specification, and their pharmaceutically acceptable salts, are PKC activators and are useful for treating diseases, such as, for example, cancer. Also disclosed are pharmaceutical compositions comprising compounds of formula I, processes for preparing compounds of formula I, and intermediates useful for preparing compounds of formula I.

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