Recorders – Writers – Receiver – only movable during recording
Patent
1993-10-25
1996-02-20
Wu, Shean
Recorders
Writers
Receiver, only movable during recording
C07D45102
Patent
active
054930260
ABSTRACT:
Disclosed are certain cocaine analogs useful for imaging of cocaine receptors and dopamine receptors. Also disclosed are analogs useful for imaging diagnostics for Parkinson's disease.
REFERENCES:
patent: 3452029 (1969-06-01), Childress et al.
patent: 5128118 (1992-07-01), Carroll et al.
patent: 5268480 (1993-12-01), Kozikowski
patent: 5310912 (1994-05-01), Neumeyer et al.
Van der Zee et al., "A comparison of the inhibitory effects of aromatic substituted benzhydryl . . . into synaptosomal preparations of the rat brain", Neuropharmacology, 17(7), 483-90, 1978.
Abstract #275, "Radioiodinated 2beta-Carbomethoxy-3beta (4-Chlorophenyl)-8-(3E-and 3Z-Iodopropen-2-yl) Nortropanes", Journal of Nuclear Medicine 33:890, 1992.
Carroll et al., "Synthesis, Ligand Binding, QSAR, and CoMFA Study . . . ", Journal of Medicinal Chemistry 34:2719-2725, 1991.
Madras et al., "N-Modified Fluorophenyltropane Analogs . . . ", Pharmacology, Biochemistry & Behavior 35:949-953, 1990.
Milius et al., "Synthesis and Receptor Binding of N-Substituted Tropane Derivatives . . . ", Journal of Medicinal Chemistry 34:1728-1731, 1991.
Boja et al. "New, Potent Cocaine Analogs: Ligand Binding and Transport Studies in Rat Striatum" European J. of Pharmacology, 184:329-332 (1990).
Brownell et al. "Use of [C-11]2.beta.-Carbomethoxy-3B-4-Fluorophenyl Tropane ([C-11 CFT) in Studying Dopamine Fiber Loss in a Primate Model of Parkinsonism" J. Nuclear Med. Abs., 33:946 (1992), Ab#512.
Canfield et al. "Autoradiographic Localization of Cocaine Binding Sites by [.sup.3 H]CFT ([.sup.3 H]WIN 35,428) in the Monkey Brain" Synapse, 6:189-195 (1990).
Carroll et al. "Probes for the Cocaine Receptor. Potentially Irreversible Ligands for the Dopamine Transporter" J. Med. Chem., 35:1813-1817 (1992).
Carroll et al. "Cocaine Receptor: Biochemical Characterization and Structure-Activity Relationships of Cocaine Analogues at the Dopamine Transporter" J. Med. Chem., 35:969-981 (1992).
Carroll et al. "Synthesis, Ligand Binding, OSAR, and CoMFA Study of 3.beta.-(p-Substituted phenyl)tropane-2.beta.-carboxylic Acid Methyl Esters" J. Med. Chem., 34:2719-2725 (1991).
Elmaleh et al. "PET Imaging Probes for the Cocaine Receptors: A Validation Study in a Nonhuman Primate Model" J. Nuclear Med. Abs., 33:946 (1992), Ab #511.
Goodman et al. "Radioiodinated 2.beta.-Carbomethoxy-3.beta.-(4-Chlorophenyl)-8-(3E-and 3Z-Iodopropen-2-YL)Nortropanes: Synthesis of Potential Radioligands for Mapping Cocaine Receptor . . . " J. Nuclear Med. Abs., 33:890 (1992), Ab #275.
Kaufman et al. "Severe Depletion of Cocaine Recognition Sites Associated With the Dopamine Transporter in Parkinson's-Diseased Striatum" Synapse, 9:43-49 (1991).
Madras ".sup.11 C-WIN 35,428 for Detecting Dopamine Depletion in Mild Parkinson's Disease" Annals of Neuro., 35:376-379 (1994).
Madras et al. "N-Modified Fluorophenyltropane Analogs of Cocaine With High Affinity for Cocaine Receptors" Pharmacol. Biochem. & Behav., 35:949-953 (1990).
Meltzer et al. "Substituted 3-Phenyltropane Analogs of Cocaine: Synthesis, Inhibition of Binding at Cocaine Recognition Sites, and Positron Emission Tomography Imaging" J. Med. Chem., 36:855-862 (1993).
Milius et al. "Synthesis and Receptor Binding of N-Substituted Tropane Derivatives. High-Affinity Ligands for the Cocaine Receptor" J. Med. Chem., 34:1728-1731 (1991).
Reith et al. "Radiolabeling of Dopamine Uptake Sites in Mouse Striatum: Comparison of Binding Sites for Cocaine, Mazindol, and GBR 12935" Arch. of Pharmacol., 345:309-318 (1992).
Reith et al. "Structural Requirements for Cocaine Congeners to Interact with Dopamine and Serotonin Uptake Sites in Mouse Brain and to Induce Sterotyped Behavior" Biochem. Pharmacol., 35:1123-1129 (1986).
Isacson, "Clinical and Preclinical PET Correlates of Parkinsonism with .sup.11 C-WIN 35,428" Annals of Neurology, 35:377-378 (1994).
Meyer et al. "Intravenously Administered Dopamine Transporter Site Radioligand Is Not Significantly Retained in Mouse Substantia Nigra or Other Sites Outside of Basal Ganglia" Annals of Neurology, 35:378-379 (1994).
Elmaleh David R.
Hanson Robert N.
Madras Bertha K.
Meltzer Peter
Chapman Lara E.
Northeastern University
Organix Inc.
President and Fellows of Harvard College
The General Hospital Corporation
LandOfFree
Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1357039