Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-11-06
2007-11-06
McKenzie, Thomas (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S211000, C546S233000, C546S309000
Reexamination Certificate
active
10569109
ABSTRACT:
The present invention relates to compounds of formula I: (I) or a pharmaceutically acceptable acid addition salt thereof, where; X is C(R3c═ or N═; R1is C2–C6alkyl, substituted C2–C6alkyl, C3–C7cycloalkyl, substituted C3–C7cycloalkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2is hydrogen, C1–C3n-alkyl, C3–C6cycloalkyl-C1–C3alkyl, or a group of formula II (II) provided that when R1is C2–C6alkyl or substituted C2–C6alkyl, R2is hydrogen or methyl; R3a, R3b, and, when X is C(R3c)═, R3c, are each independently hydrogen, fluoro, or methyl, provided that no more than one of R3a, R3b, and R3cmay be other than hydrogen; R4is hydrogen or C1–C3alkyl; R5is hydrogen, C1–C3alkyl, or C3–C6cycloalkylcarbonyl, provided that when R3ais other than hydrogen, R5is hydrogen; R6is hydrogen or C1–C6alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HT1Freceptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal.
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Hcaplus 122:105695.
Benesh Dana Rae
Blanco-Pillado Maria-Jesus
Cohen Michael Philip
Filla Sandra Ann
Hudziak Kevin John
Elrifi Ivor R.
McKenzie Thomas
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
Robinson Binta
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