Substituted 2-benzylamino-2-phenyl-acetamide compounds

Details Substituted 2-benzylamino-2-phenyl-acetamide compounds Substituted 2-benzylamino-2-phenyl-acetamide compounds

2000-09-11

2001-10-16

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S162000, C564S164000, C514S618000, C514S619000, C514S620000

Reexamination Certificate

active

06303819

ABSTRACT:

The present invention relates to novel substituted 2-benzylamino-2-phenyl-acetamide compounds, to a process for their preparation, to pharmaceutical composition containing them and to their use as therapeutic agents.
In particular, the compounds provided by the present invention are sodium channel blockers, and thus exhibit useful pharmacological properties, especially for the treatment and alleviation of chronic and neuropathic pain. Chronic and neuropathic pain are associated with prolonged tissue damage or injuries to the peripheral or central nervous system and result from a number of complex changes in nociceptive pathways, including ion channel function. Clinical manifestations of chronic pain include a sensation of burning or electric shock, feelings of bodily distortion, allodynia and hyperpathia.
Despite the large number of available analgesics, their use is limited by severe side effects and modest activity in some pain conditions. Therefore there is still a clear need to develop new compounds.
Accordingly, one object of the present invention is to provide novel compound having the following formula (I)
wherein:
n is zero, 1, 2 or 3;
X is —O—, —S—, —CH
2
— or —NH—; each of R, R
1
, R
2
and R
3
, independently, is hydrogen, C
1
-C
6
alkyl, halogen, hydroxy, C
1
-C
6
alkoxy or trifluoromethyl;
each of R
4
and R
5
, independently, is hydrogen, C
1
-C
6
alkyl or C
3
-C
7
cycloalkyl; and the pharmaceutically acceptable salts thereof.
A —(CH
2
)
n
— chain may be a branched or straight chain.
Alkyl and alkoxy groups may be branched or straight groups. Representative examples of C
1
-C
6
alkyl groups include C
1
-C
4
alkyl groups such as methyl, ethyl, n- and iso-propyl, n-, iso-, sec- and tert-butyl.
Representative examples of C
1
-C
6
alkoxy groups include C
1
-C
4
alkoxy groups such as methoxy and ethoxy.
A C
3
-C
7
cycloalkyl group is for instance cyclopropyl, cyclopentyl or cyclohexyl, in particular cyclopentyl or cyclohexyl.
A halogen atom is fluorine, bromine, chlorine or iodine, in particular, chlorine or fluorine.
Pharmaceutically acceptable salts of the compounds of the invention include acid addition salts with inorganic, e.g. nitric, hydrochloric, hydrobromic, sulphuric, perchloric and phosphoric acids or organic, e.g. acetic, trifluoroacetic, propionic, glycolic, lactic, oxalic, malonic, malic, maleic, tartaric, citric, benzoic, cinnamic, mandelic and salicylic acids.
The compounds of the invention have asymmetric carbon atoms and therefore they can exist either as racemic mixtures or as individual optical isomers (enantiomers).
Accordingly, the present invention also include within its scope all the possible isomers and their mixtures and both the metabolites and the pharmaceutically acceptable bio-precursors (otherwise known as pro-drugs) of the compounds of the invention.
Preferred compounds of the invention are the compounds of formula (I) wherein
n is 1 or 2;
X is —O—;
each of R, R
1
, R
2
and R
3
, independently, is hydrogen, or halogen;
R
4
and R
5
are hydrogen; and the pharmaceutically acceptable salts thereof.
Examples of specific compounds of the invention are:
2-[4-benzyloxybenzylamino]-2-phenyl-acetamide;
2-[4-(3-fluorobenzyloxy)benzylamino]-2-phenyl-acetamide;
2-[4-(3-chlorobenzyloxy)benzylamino]-2-phenyl-acetamide;
2-[4-(3-bromobenzyloxy)benzylamino]-2-phenyl-acetamide;
2-[4-(2-fluorobenzyloxy)benzylamino]-2-phenyl-acetamide;
2-[4-(3-fluorobenzyloxy)benzylamino]-2-(2-fluorophenyl)-acetamide;
2-[4-(3-fluorobenzyloxy)benzylamino]-2-(3-fluorophenyl)-acetamide; and
2-[4-(3-chlorobenzyloxy)benzylamino]-2-(3-fluorophenyl)-acetamide,
if the case either as a single isomer or as a mixture thereof, and the pharmaceutically acceptable salts thereof.
Object of the present invention is also to provide a compound of formula (I), as defined above, or a pharmaceutically acceptable salt thereof for use as a therapeutic substance, in particular for treating chronic and neuropathic pain.
An aspect of this invention relates to the use of a compound of formula (I), as defined above, or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use in treating chronic and neuropathic pain.
A further aspect of this invention relates to a method of treating a mammal, including humans, in need of a sodium channel-blocking agent, said method comprising administering thereto an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.
Neuropathic pain conditions in a mammal can thus be alleviated and treated. Examples of neuropathic pain conditions responsive to sodium channel-blocking agents include:
peripheral neuropathies, such as trigeminal neuralgia, postherapeutic neuralgia, diabetic neuropathy, glossopharyngeal neuralgia, radiculopathy, and neuropathy secondary to metastatic infiltration, adiposis dolorosa and burn pain; and
central pain conditions following stroke, thalamic lesions and multiple sclerosis.
‘Treatment’ as used herein covers any treatment of a condition in a mammal, particularly a human, and includes:
(i) preventing the disease from occurring in a subject which may be predisposed to the disease, but has not yet been diagnosed as having it;
(ii) inhibiting the condition, i.e., arresting its development; or
(iii) relieving the condition, i.e., causing regression of the disease.
The term ‘disease state which is alleviated by treatment with a sodium channel blocker’ as used herein is intended to cover all disease states which are generally acknowledged in the art to be usefully treated with sodium channel blockers in general, and those disease states which have been found to be usefully treated by the specific sodium channel blocker of our invention, the compound of formula (I).
The compounds of the invention and the salts thereof can be obtained, for instance, by a process comprising:
a) reacting a compound of formula (II)
wherein n, R
2
, R
3
and X are as defined above, with a compound of formula (III)
wherein R, R
1
and R
4
are as defined above, thus obtaining a compound of formula (I) in which R
5
is hydrogen; or
b) reacting a compound of formula (IV)
wherein R, R
1
, R
2
, R
3
, R
4
, n and X are as defined above, with a compound of formula (V), (VI) or (VII)
R′
5
W  (V)
R″
5
CHO  (VI)
wherein W is a halogen atom; R′
5
is a C
1
-C
6
alkyl or C
3
-C
7
cycloalkyl and R″
5
is hydrogen or C
1
-C
5
alkyl, and p is 2-6, thus obtaining a compound of the invention in which R
5
is C
1
-C
6
alkyl or C
3
-C
7
cycloalkyl; and, if desired, converting a compound of the invention into another compound of the invention and/or, if desired, converting a compound of the invention into a pharmaceutically acceptable salt and/or, if desired, converting a salt into a free compound.
All the processes described hereabove are analogy processes and can be carried out according to well known methods in organic chemistry.
A compound of formula (IV) is a compound of formula (I) in which R
5
is hydrogen.
The reaction of a compound of formula (II) with a compound of formula (III) to give a compound of formula (I) or (IV) is a reductive amination reaction which can be carried out according to well known methods. According to a preferred embodiment of the invention it may be performed under nitrogen atmosphere, in a suitable organic solvent, such as an alcohol, e.g. a lower alkanol, in particular methanol, or in acetonitrile, at a temperature ranging from about 0° C. to about 40° C., in the presence of a reducing agent, the most appropriate being sodium cyanoborohydride.
Occasionally molecular sieves can be added to the reaction mixture for facilitating the reaction.
In a compound of formula (V) the halogen W is preferably iodine. The alkylation reaction of a compound of formula (IV) with a compound of formula (V) can be carried out in a suitable organic solvent, such as an alcohol, e.g. methanol, ethanol or isopropanol, in particular in ethanol, at a temperature ranging fro

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