Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-02-22
2005-02-22
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S375000, C548S179000, C548S217000
Reexamination Certificate
active
06858633
ABSTRACT:
Substituted 2-phenylbenzazole compounds of formula (I) wherein X represents S or O and Q represents a direct bond, —CH2— or —CH═Ch—, exhibt selective antiproliferactive activity in respect of mammalian tumour cells. At least in preferred enbodiments the benzene ring of the benzazole nucleus has a halogen substituent, preferably flourine, and the 2-phenyl group has a 4′-amino substituent which may be conjugated with an amino acid to provide a water soluble amino acid amide prodrug or salt thereof.
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Hauser, Hermann, “2-Aminophenyl benzothiazoles”Chemical Abstracts22:9 (May 10, 1928) 1590 (Abstract); andHelv. Chim. ACTA11 (1928) 198-209 (article).
Hutchinson et al., “The regiospecific synthesis of 5- and 7-monosubstituted and 5,6-disubstituted 2-arylbenzothiazoles ”Tetrahedron Letters41 (2000) 425-428.
Chua Mei-Sze
Hutchinson Ian P.
Poole Tracey D.
Stevens Malcolm F. G.
Westwell Andrew D.
Cancer Research Technology Limited
Pillsbury & Winthrop LLP
Solola Taofiq
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