Substituted 2-aminothiochromones

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Allergen or component thereof

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260327TH, C07D33506

Patent

active

040137716

ABSTRACT:
This invention relates to substituted 2-aminothiochromones of the general structure I: ##STR1## wherein R.sub.1 and R.sub.2 may be hydrogen; lower alkyl or lower alkoxy of 1 to 6 carbon atoms; or halogen such as chloro or bromo; and X may be cyano or carboxamido. The compounds are prepared using a thiosalicylic acid or a substituted thiosalicylic acid as starting material.
The compounds of this invention are active in the prevention of allergic and asthmatic reactions in mammals.

REFERENCES:
patent: 3804857 (1974-04-01), Cairns et al.
patent: 3825574 (1974-07-01), Brown
patent: 3828073 (1974-08-01), Zinnes et al.
patent: 3853921 (1974-12-01), Klutchko et al.
patent: 3862140 (1975-01-01), Zinnes et al.
patent: 3862143 (1975-01-01), Klutchko et al.
patent: 3868379 (1975-02-01), Zinnes et al.
patent: 3932466 (1976-01-01), Brown et al.

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