Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1993-10-04
1994-10-25
Chang, Celia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564347, 564352, 564353, 564354, 549304, 549466, A61K 31135, C07C21710
Patent
active
053589718
ABSTRACT:
Optically active or racemic compounds are provided having the formula ##STR1## where R.sub.2, R.sub.3 and R.sub.4 are selected from the group consisting of H and OA with the provision that at least one of R.sub.2, R.sub.3 and R.sub.4 is H, that R.sub.2 and R.sub.4 are not both OA; A is H or is selected from the group consisting of hydrocarbyl radicals, said hydrocarbyl radicals being further optionally substituted with radicals selected from the group consisting of ##STR2## R.sub.5 is selected from the group consisting of alkyl and aromatic residues, preferably radicals having between 1 and 12 carbon atoms, including alkyl, alkyl substituted with aryl radicals, and aryl radicals substituted with alkyl radicals; n is an integer between 1 and 4; R.sub.6 is an alkyl chain comprising between 1 and 4 carbon atoms; X is oxygen; and R.sub.1 is selected from the group consisting of ##STR3## wherein Y is as defined in the specification, and a is an integer of from zero to 3.
These compounds are useful in treatment of disorders of the central nervous, cardiovascular, and endocrine systems, such as for inducing anorexia and weight loss in humans.
REFERENCES:
patent: 5070106 (1991-12-01), Casagrande
McDermed et al "Synthesis and Pharmacology of Some 2-Aminotetralins" J. Med Chem. 18 362-367 (1975).
Minaskanian Gevork
Peck James V.
Chang Celia
Hammond Richard J.
Whitby Research, Inc.
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