Substituted 2-aminoacetamides and the use thereof

Details Substituted 2-aminoacetamides and the use thereof Substituted 2-aminoacetamides and the use thereof

2011-01-18

2011-01-18

Habte, Kahsay T (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C546S300000, C549S410000

Reexamination Certificate

active

07872127

ABSTRACT:
The invention is directed to substituted2-aminoacetamides represented by formula (II):and to pharmaceutically acceptable salts and prodrugs thereof, wherein the substituents are defined herein. The invention is also directed to the use of substituted2-aminoacetamides in methods for the treatment of neuronal damage following global and focal ischemia, and for the treatment, prevention or amelioration of pain, as anticonvulsants, as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

REFERENCES:
patent: 3576864 (1971-04-01), Kuppuswamy
patent: 4725608 (1988-02-01), Nakaguchi et al.
patent: 4927835 (1990-05-01), Kise et al.
patent: 5236957 (1993-08-01), Dostert et al.
patent: 5391577 (1995-02-01), Dostert et al.
patent: 5446066 (1995-08-01), Varasi et al.
patent: 5449692 (1995-09-01), Varasi et al.
patent: 5455273 (1995-10-01), Maier et al.
patent: 5475007 (1995-12-01), Cai et al.
patent: 5482964 (1996-01-01), Hays
patent: 5498610 (1996-03-01), Chenard
patent: 5502079 (1996-03-01), Dostert et al.
patent: 5741818 (1998-04-01), Dimmock
patent: 5849373 (1998-12-01), Barbour et al.
patent: 5849737 (1998-12-01), Chaplan et al.
patent: 5945454 (1999-08-01), Pevarello et al.
patent: 6281211 (2001-08-01), Cai et al.
patent: 6306903 (2001-10-01), Pevarello et al.
patent: 44 21 582 (1996-01-01), None
patent: 0 415 413 (1991-03-01), None
patent: 6-211763 (1994-08-01), None
patent: WO 90/14334 (1990-11-01), None
patent: WO 94/22808 (1994-10-01), None
patent: WO 94/22809 (1994-10-01), None
patent: WO 95/29165 (1995-11-01), None
patent: WO 9634866 (1996-11-01), None
patent: WO 96/40628 (1996-12-01), None
patent: WO 97/05102 (1997-02-01), None
patent: WO 98/19998 (1998-05-01), None
patent: WO 98/43964 (1998-10-01), None
patent: WO 98/47869 (1998-10-01), None
patent: WO 99/35125 (1999-07-01), None
patent: WO 99/39712 (1999-08-01), None
Anonymous, “Neurogen licenses National Institutes of Health (NIH) anticonvulsants,”SCRIP World Pharmaceutical News1773:14, Informa UK Ltd. (1992).
Anonymous, “Cambridge NeuroScience's grant for channel blockers,”SCRIP World Pharmaceutical News1870:8 Informa UK Ltd. (1993).
Bensimon, G., et al., “A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis,”New Engl. J. Med. 330:585-591, Massachusetts Medical Society (1994).
Brown, C.M., et al., “Neuroprotective properties of lifarizine compared with those of other agents in the mouse model of focal cerebral ischaemia,”Br. J. Pharmacol. 115:1425-1432, Stockton Press (1995).
Catterall, W.A., “Common modes of drug action on Na+ channels: local anesthetics, antiarrhythmics and anticonvulsants,”Trends Pharmacol. Sci. 8:57-65, Elsevier (1987).
Catterall, W.A., “Neurotoxins That Act on Voltage-Sensitive Sodium Channels in Excitable Membranes,”Ann. Rev. Pharmacol. Toxicol. 20:15-43, Annual Reviews (1980).
Catterall, W.A., “Structure and Function of Voltage-Sensitive Ion Channels,”Science242:50-61, American Association for the Advancement of Science (1988).
Denicoff, K.D., et al., “Efficacy of Carbamazepine Compared With Other Agents: A Clinical Practice Survey,”J. Clin. Psychiatry55:70-76, Physicians Postgraduate Press (1994).
Dimmock, J.R., et al., “(Aryloxy)aryl Semicarbazones and Related Compounds: A Novel Class of Anticonvulsant Agents Possessing High Activity in the Maximal Electroshock Screen,”J. Med. Chem. 39:3984-3997, American Chemical Society (1996).
Graham, S.H., et al., “Neuroprotective Effects of a Use-Dependent Blocker of Voltage-Dependent Sodium Channels, BW619C89, in Rat Middle Cerebral Artery Occlusion,”J. Pharmacol. Exp. Ther. 269:854-859, American Society for Pharmacology and Experimental Therapeutics (1994).
Pevarello, P., et al., “Synthesis and Anticonvulsant Activity of a New Class of 2-[(Arylalkyl)amino] alkanamide Derivatives,”J. Med. Chem. 41:579-590, American Chemical Society (1998).
Stys, P.K., et al., “Ionic Mechanisms of Anoxic Injury in Mammalian CNS White Matter: Role of Na- Channels and Na+-Ca2+Exchanger,”J. Neurosci. 12:430-439, Society for Neuroscience (1992).
Taylor, C.P., and Meldrum, B.S., “Na+channels as targets for neuroprotective drugs,”Pharmacol. Sci. 16:309-316, Elsevier (1995).
International Search Report for International Application No. PCT/US98/24965, Commissioner of Patents and Trademarks, Alexandria, VA, mailed on Mar. 1, 1999.
Patent Abstracts of Japan, English language abstract for Japanese Application No. 6-211763, published Aug. 2, 1994 (listed as FP5 on accompanying PTO/SB/08A).
Dialog File 351, Accession No. 7441379, English language abstract for Application No. DE 44 21 582, published Jan. 4, 1996 (listed as FP7 on accompanying PTO/SB/08A).
Interference Document for Interference No. 105,394,Paolo Pevarello, Mario Varasi, Patricia Salvati, and Claes Post v. Nancy C. Lan, Yang Wang, and Sui Xiong Cai, “Decision-Preliminary Motions-Bd.R. 125”, 65 pages, filed Jan. 12, 2007.
Interference Document for Interference No. 105,394,Paolo Pevarello, Mario Varasi, Patricia Salvati, and Claes Post v. Nancy C. Lan, Yang Wang, and Sui Xiong Cai, “Judgment Preliminary Motions-Bd.R. 127”, 3 pages, filed Jan. 12, 2007.

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