Substituted 2-amidotetralins as melatonin agonists and antagonis

Details Substituted 2-amidotetralins as melatonin agonists and antagonis Substituted 2-amidotetralins as melatonin agonists and antagonis

1989-09-25

1991-12-10

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514616, 514617, 514619, 514624, 514625, 514628, 514629, 564153, 564155, 564157, 564184, 564189, 564190, 564192, 564211, 564218, 564222, A61K 31165, A61K 3116, C07C23365, C07C23363

Patent

active

050718754

ABSTRACT:
The present invention relates generally to compounds having melatonin receptor activities and in particular to substituted 2-amidotetralin derivatives; to pharmaceutical preparations comprising such compounds; and to methods for using these compounds as therapeutic and diagnostic reagents.

REFERENCES:
patent: 4035512 (1977-07-01), Sugihara et al.
patent: 4091018 (1978-05-01), Asato
patent: 4107206 (1978-08-01), Hewett et al.
patent: 4254268 (1981-03-01), Strong
patent: 4320148 (1982-03-01), DeMarinis
Arendt, J. et al., Br. Med. J., 292:1170 (1986).
Arendt, J., Oxford Reviews of Reproductive Biology, 8:266-320 (1986).
Besharse, J. C., Progress in Retinal Research, 1:81-124 (1982).
Beyer, H., Chem. Berichte, 70:1101-1110 (1937).
Birau, N., Melatonin-Current Status and Perspectives, 297-326 (1985).
Birkeland, A. J., Neuroendocrinology, 34:126-131 (1982).
Cardinali, D. P., Endocrinol. Rev., 2:327-346 (1981).
Cassone, V. M., et al., Journal of Biological Rhythms, 1:219-229 (1986).
Darrow, J. M., et al., Journal of Biological Rhythms, 1:39-54 (1985).
Dubocovich, M. L., The Journal of Pharmacology and Experimental Therapeutics, 246:902-910 (1988).
Dubocovich, M. L., FASEB, 2:2765-2773 (1988).
Dubocovich, M. L., et al., Proc. Nat'l. Acad. Sci. USA, 84:3916-3920 (1987).
Dubocovich, M. L., The Journal of Pharmacology and Experimental Therapeutics, 234:395-401 (1985).
Dubocovich, M. L., European Journal of Pharmacology, 105:193-194 (1984).
Dubocovich, M. L., Nature, 306:782-784 (1983).
Duncan, M. J., et al., Endocrinology, 125:1011-1018 (1989).
Ferrier, I. N., et al., Clinical Endocrinology, 17:181-187 (1982).
Fine, S. A., et al., J. Org. Chem., 32:4132 (1967).
Hacksell, U., et al., J. Med. Chem., 22:1469-1475 (1979).
Heward, C. B., et al., Life Sciences, 17:1167-1178 (1975).
Horn, A. S., et al., Eur. J. Med. Chem., 23:325-328 (1988).
Horn, A. S., et al., J. Med. Chem., 21:825-828 (1978).
Iguchi, H., et al., J. Clin. Endocrinol. & Metab., 55:27-29 (1982).
Iuvone, P. M., The retina: A Model for Cell Biology Studies, 2:1-72 (1986).
Jimerson, D. C., et al., Life Sciences, 20:1501-1508 (1977).
Kauppila, A., et al., J. Clin. Endocrinol. & Metab., 65:823-828 (1987).
Krauss, G., et al., Inv. Ophthalm. Vis. Sci. vol. 26, Abst. 49 (1988).
Lewy, A. J., Science, 235:352-354 (1987).
Lewy, A. J., et al., Proceedings of the Society for Experimental Biology and Medicine, 183:11-18 (1986).
Maestroni, G. J. M., et al., Clin. Exp. Immunol., 68:384-391 (1987).
Menaker, M., Vertebrate Circadian Systems, 1-12 (1982).
Minneman, K. P., et al., Life Sci., 17:1189-1200 (1975).
Redman, J., et al., Science, 219:1089-1091 (1983).
Reppert, S. M., et al., Science, 242:78-81 (1988).
Rosenthal, N. E., et al., Arch. Gen. Psychiatric, 41:72-80 (1984).
Smith, J. A., et al., J. Pharmacol., 31:246-248 (1979).
Smythe, G. A., et al., Nature (London), 244:230-231 (1973).
Stanberry, L. R., Endocrinology, 113:469-475 (1983).
Tamarkin, L., et al., Science, 227:714-720 (1985).
Tamarkin, L., et al., Science, 216:1003-1005 (1982).
Underwood, H., et al., Physiology & Behavior, 35:267-270 (1985).
Vriend, J., Med. Hypotheses, 4:376-387 (1978).
Weinstock, J., et al., J. Med. Chem., 29:1615-1627 (1986).
Wetterberg, L., Neural Transm., 13:289-310 (1978).
Condon, M. et al., "Phenylpiperazinotetrahydronaphthols and derivatives", CA, vol. 94, 139840h (1981) +10.sup.th Collect Index.
Ames et al., "The Synthesis of Alkoxy-1,2,3,4-tetrahydronaphthalene Derivatives Part I etc.", J. Chem. Soc. 2636, Apr. 1965.

Affiliated with

Also associated with

Rating

Substituted 2-amidotetralins as melatonin agonists and antagonis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted 2-amidotetralins as melatonin agonists and antagonis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted 2-amidotetralins as melatonin agonists and antagonis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1040969