Substituted 2-acylpyridine-.beta.-(N)-hetaryl-hydrazones and med

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514183, 514256, 514269, 514275, 544284, 544320, A61K 31505

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active

050844580

ABSTRACT:
Substituted 2-acylpyridine-.alpha.-(N)-hetarylhydrazones are described, which are suitable as active substances for the treatment of antimicrobial and in particular antimycobacterial diseases, as well as as active substances for the treatment of malaria or malignant tumors. The compounds have a marked synergistic activity combined with inhibitors of folate synthase, dihydrofolic acid reductase, DNA-synthesis and RNA-synthesis.

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Miakelson, Jour. Inorg. Nucl. Chem., vol. 43, pp. 123-126 (1981).
Pellerano et al. Chem. Abstr., vol. 91 entry 175157n (1979).

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