Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-04-24
1999-02-02
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544295, 544238, 544122, 544123, 544324, 544296, 540601, 540481, 514212, 514183, 5142358, 5142365, 514252, 514269, C07D40110, A61K 31505
Patent
active
058665838
ABSTRACT:
Compounds of formula I ##STR1## wherein R.sup.1 is lower-alkoxy, R.sup.2 is bromine, lower-alkoxy or hydroxy, R.sup.3 is hydrogen, lower-alkyl, cycloalkyl, aryl, heterocyclyl, aralkyl, heterocyclyl-lower-alkyl or cyano, R.sup.4 and R.sup.5 each independently are hydrogen, lower-alkyl, lower-alkoxy, halogen, hydroxy, amino, di(lower alkyl)amino, cyano or nitro and Q is ethynylene or vinylene, or pharmaceutically usable salts thereof, the use of these compounds and their salts as therapeutically active substances; medicaments based on these substances and their production; the use of these substances as medicaments and for the production of antibacterially-active medicaments; as well as the manufacture of the compounds of formula I and their pharmaceutically acceptable salts and intermediates for their manufacture.
REFERENCES:
patent: 3341541 (1967-09-01), Hoffer
patent: 4013644 (1977-03-01), Lenz
patent: 4515948 (1985-05-01), Kompis et al.
patent: 4594199 (1986-06-01), Thottathil
Roth et al., J. Med. Chem. 32, 1989 pp. 1949-1958.
Nagakura et al., Phytochemistry, 32(3), 1993 pp. 761-765.
Tietze et al. Chemische Berichte, 125, 1992, pp. 2571-2576.
Yamaguchi et al., J. Am. Chem. Soc. 110, 1988, pp. 2186-2187.
D.P. Baccanari, Biochemistry 20, pp. 1710-1716 (1981).
P.G. Hartman et al. FEBA Letters 242, pp. 157-160 (1988).
Guerry Philippe
Stalder Henri
Wyss Pierre-Charles
Epstein William H.
Ford John M.
Hoffmann-La Roche Inc.
Johnston George W.
Parise John P.
LandOfFree
Substituted 2,4-diaminopyrimidines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted 2,4-diaminopyrimidines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted 2,4-diaminopyrimidines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1117761