Substituted (2,3-dihydro-1-oxo-1H-inden-5-yl)alkanoic acids, the

Details Substituted (2,3-dihydro-1-oxo-1H-inden-5-yl)alkanoic acids, the Substituted (2,3-dihydro-1-oxo-1H-inden-5-yl)alkanoic acids, the

1986-11-10

1988-06-28

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 51, C07C 5986

Patent

active

047540613

ABSTRACT:
The invention relates to novel substituted (2,3-dihydro-1-oxo-1H-inden-5-yl)alkanoic acids, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

REFERENCES:
patent: 4249021 (1981-02-01), Cragoe, Jr.
patent: 4342776 (1982-08-01), Cragoe, Jr. et al.
Williams J., Organic Chem. 44, 4060, (1979).
Cragoe, E. J., Jr., J. Med. Chem., 1982, 25 567-579.
O. W. Woltersdorf, et al., J. Med. Chem., 20 1400 (1977).
E. J. Cragoe, et al., J. Med. Chem., 21 437 (1978).
J. H. Garcia et al., Virchows Archiv. 25 191 (1977).
J. Med. Chem. 25 567 (1982).
Seminars in Neurological Surgery, Neural Traums L. F. Marshall et al., 347-351, (1979).
H. K. Kimelberg et al., Brain Res. 105, (1976), 309-323.
H. K. Kimelberg, Rasin Res. 13 111, (1979).
H. K. Kimelberg et al. 177 (1979) 533.

Affiliated with

Also associated with

Rating

Substituted (2,3-dihydro-1-oxo-1H-inden-5-yl)alkanoic acids, the does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted (2,3-dihydro-1-oxo-1H-inden-5-yl)alkanoic acids, the, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted (2,3-dihydro-1-oxo-1H-inden-5-yl)alkanoic acids, the will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1915832