Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters

Details Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters

1983-09-29

1985-11-26

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544116, 544119, 560 43, 562433, 564443, C07D23980, C07D40304, C07D41304, A61K 31505

Patent

active

045555710

ABSTRACT:
The synthesis of substituted 2(1H)-quinazolinone-1-alkanoic acids and their esters is described. The novel quinazolinones are renal vasodilators and as such reduce vascular resistance to renal blood flow. The quinazolinones are useful as cardiovascular agents.

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Budesinsky et al., "Chem. Commun. Collection, Czechoslov", vol. 37, 1972, pp. 2779-2783.
Beck et al., "Jorn. Org. Chem.", vol. 39(13), 1974, pp. 1839-1841.
Blunt et al., "Aust. J. Chem.", vol. 32, 1979, pp. 1045-1054.
Mulvey et al., "Tetrahedron Letters", No. 16, 1978, pp. 1419-1420.

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