Substituted 1H-quinazoline-2,4-diones useful as AMPA...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S283000, C546S268100, C548S255000, C548S373100, C548S579000, C549S429000

Reexamination Certificate

active

07655666

ABSTRACT:
The present invention relates to 1H-Quinazoline-2,4-diones of formula (I)wherein R1and R2are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.

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Ohmori et al., “6-(1H-Imidazol-1-y1)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor”, J. Med. Chem., vol. 37 (1994), pp. 467-475
Takano et al., “Synthesis and AMPA Receptor Antagonistic Activity of a Novel Class of Quinoxalinecarboxylic Acid with a Substituted Phenyl Group at the C-7 Position”, Bioorg. Med. Chem. Lett. vol. 13 (2003), pp. 3521-3525.
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Catarzi et al., “Synthesis and Biological Evaluation of Analogues of 7-Chloro-4,5-dihydro-4-oxo-8- (1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic Acid (TQX-173) as Novel Selective AMPA Receptor Antagonists”, J. Med. Chem. vol. 47, No. 1 (2004), pp. 262-272.
Novartis AG, Office Action issued in Singapore Patent App. No. 200706385-2, Oct. 5, 2009, 8 pages.

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