Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-11-29
1987-09-15
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514825, 514826, 514886, 548561, 548562, C07D207337, A61K 3140
Patent
active
046940189
ABSTRACT:
The compounds of the present invention comprise substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives thereof represented by the formula: ##STR1## wherein: R represents hydroxy, alkoxy of from 1 to 6 carbon atoms, inclusive, or amino; R.sup.1 represents hydrogen or acyl of from 2 to 7 carbon atoms, inclusive; and X represents hydrogen, halogen, hydroxy or alkoxy of from 1 to 6 carbon atoms, inclusive. The compounds of the present invention are 5-lipoxygenase inhibitors and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.
REFERENCES:
patent: 3168527 (1965-02-01), Short
patent: 3168529 (1965-02-01), Short
patent: 3168531 (1965-02-01), Short
patent: 3168532 (1965-02-01), Short
patent: 3471513 (1969-10-01), Chinn
patent: 3475451 (1969-10-01), Chinn
patent: 3542788 (1970-11-01), Chinn et al.
Berch Mark L.
G. D. Serale & Co.
Kanady Mary Jo
Matukaitis Paul D.
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