Substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-on

Details Substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-on Substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-on

1989-07-17

1991-06-25

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548550, C07D20726, C07D207335, A61K 3140

Patent

active

050268619

ABSTRACT:
Novel cyclic vinylogous N-hydroxy-N-methylureas are useful in the treatment of leukotriene mediated conditions such as asthma and rheumatoid arthritis.

REFERENCES:
Summers, J. B., et al., J. Med. Chem., 30, 574-580, 1987.
Summers, J. B., et al., J. Med. Chem., 30, 2121-2126.
Tateson, J. E., et al., Br. J. Pharmacol., 94, 528-539.

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