Substituted 1,3-dialkylpyrido[4,3-d]pyrimidine-2,4-diones

Details Substituted 1,3-dialkylpyrido[4,3-d]pyrimidine-2,4-diones Substituted 1,3-dialkylpyrido[4,3-d]pyrimidine-2,4-diones

1987-04-08

1989-02-28

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, 544311, A61K 31505, C07D47104

Patent

active

048086185

ABSTRACT:
The present invention relates to a novel pyrido[4,3-d]pyrimidine derivative having the formula (I): ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is a lower alkyl group; R.sub.3 is hydrogen, halogen, hydroxy, amino, hydroxyamino, imino, hydrazino or a lower alkylamino group which may optionally have hydroxy, amino or a lower alkylamino group; and R.sub.4 is hydrogen, amino, --NH.sup..crclbar. or a lower alkyl group which may optionally have hydroxy, amino or a lower alkylamino group; and pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents, for example, for the treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.

REFERENCES:
patent: 3186991 (1965-06-01), Ohnacker

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