Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids

Details Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids

1986-08-15

1987-08-11

Ceperley, Mary E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514282, 514411, 548432, A61K 3162, A61K 31445, A61K 3140, C07D49304

Patent

active

046862137

ABSTRACT:
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at position 8. The derivatives are useful anti-inflammatory and analgesic agents and methods and chemical intermediates for their preparation are also disclosed. Included are compounds of the formula ##STR1## wherein R.sup.1 is --H or lower alkyl containing 1 to 3 carbon atoms; R.sup.2 is --NH.sub.2, --NHCHO, --NHCONH.sub.2, --OCH.sub.3, oxo; R.sup.3 is --H or lower alkyl containing 1 to 3 carbon atoms and the pharmaceutically acceptable salts thereof when R.sup.1 is --H.

REFERENCES:
patent: 3843681 (1974-10-01), Demerson et al.
patent: 3939178 (1976-02-01), Demerson et al.
patent: 3974179 (1976-08-01), Demerson et al.
M. Cayen et al, Chem. Abstracts, 96: 170w, (1982), The Metabolic Disposition of Etodolac in Rats, Dogs and Man.
C. Demerson et al, J. Med. Chem., 18, 189 (1975).

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