Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acid

Details Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acid Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acid

1987-09-21

1989-03-07

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514282, 514411, 548432, A61K 3140, C07D49152

Patent

active

048106992

ABSTRACT:
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1,5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.

REFERENCES:
patent: 3843681 (1974-10-01), Demerson et al.
patent: 3939178 (1976-02-01), Demerson et al.
patent: 3974179 (1976-08-01), Demerson et al.
patent: 4012417 (1977-03-01), Demerson et al.
patent: 4585877 (1986-04-01), Demerson et al.
patent: 4670462 (1987-06-01), Katz et al.
patent: 4686213 (1987-08-01), Ferdinandi et al.
Demerson et al., Journal of Medicinal Chemistry, vol. 19, No. 3, pp. 391-395 (1976).
McOmie, "Protective Groups in Organic Chemistry", Plenum Press, london & New York, 1973, p. 149.
Greene, "Protective Groups in Organic Synthesis", John Wiley & Sons, New York, 1981, p. 95.

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