Substituted-1,2-dihydro-2-oxonicotinyl-cephalosporins

Details Substituted-1,2-dihydro-2-oxonicotinyl-cephalosporins Substituted-1,2-dihydro-2-oxonicotinyl-cephalosporins

1976-01-19

1977-10-11

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 2602391, 544 27, 544 28, C07D50120, A61K 31545, C07D49944

Patent

active

040534707

ABSTRACT:
Novel organic amide compounds which are N-[6-[(substituted amino)phenyl] 1,2-dihydro-2-oxonicotinyl]penicillin and cephalosporin type compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or cephalosporin or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding N-6-[(substituted amino)phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-amino-penicillanic acid, 7-aminocephalosporanic acid, 7-amino-3-methylceph-3-em-4-carboxylic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(substituted amino)phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

REFERENCES:
patent: 3948903 (1976-04-01), Doub et al.
patent: 3954734 (1976-05-01), Doub et al.

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