Substituted 1,2,3 triazole angiotensin II antagonists

Details Substituted 1,2,3 triazole angiotensin II antagonists Substituted 1,2,3 triazole angiotensin II antagonists

1991-07-10

1993-02-23

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142362, 514252, 514255, 514326, 514381, 548250, 548252, 548253, 548254, 548255, 544132, 544366, 546210, A61K 3141, A61K 31535, C07D24904, C07D40114

Patent

active

051890488

ABSTRACT:
This invention includes substituted pyrroles, pyrazoles and triazoles, processes for their preparation, pharmaceutical compositions containing them, and their use as antihypertensive agents, and as a treatment for congestive heart failure in mammals. The heterocyclic compounds of the invention have the structural formula (I) ##STR1## or pharmaceutically suitable salts thereof.

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Pals, et al., Cir. Res., 29, 673 (1971).
Streeten & Anderson, Handbook of Hypertension, vol. 5, Clinical Pharmacology of Antihypertensive Drugs, A. E. Doyle (Ed.) Elsevier Sci. Publ. BV., p. 246

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