Substitute for human blood and a method of making the same

Details Substitute for human blood and a method of making the same Substitute for human blood and a method of making the same

1985-12-20

1988-04-19

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, A61K 3700

Patent

active

047389524

ABSTRACT:
The method of this invention yields a two phase liquid aqueous system which replicates the two phase heterogeneous physiochemical system of naturally occurring whole human blood. The method produces a composition of matter which comprises a whole blood substitute when polymerized hemoglobin or pyridoxylated-polymerized hemoglobin and preferably, other specific additives are incorporated. When said blood substitute is processed further, a microencapsulated composition with time release characteristics that can transport oxygen is produced. The invention overcomes the obstacles that have prevented the use of modified hemoglobins like pyridoxylated-polymerized hemoglobin in the preparation of oxygen transport systems.

REFERENCES:
patent: 3169094 (1965-02-01), Wretlind
patent: 4133874 (1979-01-01), Miller et al.
patent: 4252793 (1981-02-01), Altman
patent: 4321259 (1982-03-01), Nicolau et al.
patent: 4343797 (1982-08-01), Ecanow et al.
Blood Policy & Technology, Jan. 1985, Office of Technology Assessment, pp. 136-150.
Gessner G. Hawley, ed., The Condensed Chemical Dictionary, 9th ed., (New York: Van Nostrand Reinhold Company, 1977). p. 213.
Arthur Osol, ed., Remington's Pharmaceutical Sciences, (Easton, Pa.: Mack Publishing Co., 1975), p. 315.
J. McMullen et al., "Pectin-Gelatin Complex Coacervates", Journal of Pharmaceutical Science, vol. 71, No. 6, (Jun., 1982), pp. 628-633.
A. Veis and C. Aranyi, "Phase Separation in Polyelectrolyte Sytems", Journal of Physical Chemistry, vol. 64, (1960), pp. 203-210.
Dowben, Robert M., General Physiology, A Molecular Approach, Harper & Row, N.Y., 1969, pp. 146-147.
Considine, D. M., Van Nostrand's Scientific Encyclopedia, 6th ed., Van Nostrand Reinhold Co., N.Y., 1983, pp. 1769-1770.
Watanabe et al., Chemical Abstracts, vol. 81, (1974), p. 16715v.
Kaplan et al., Chemical Abstracts, vol. 83, (1975), p. 53540w.
Vinograd-Finkel et al., Chemical Abstracts, vol. 77, (1972), p. 86318j.
E. Selkurt, ed., Physiology, 2nd ed., (Boston: Little, Brown & Co., 1966), p. 216.
A. Guyton, Basic Human Physiology: Norman Functions and Mechanisms of Disease, (Philadelphia: W. B. Saunders Co., 1971), p. 157.
M. Ashwood, "Polyvinylpyrolidone Solutions Used in Plasma Expanders: Potential Carcinogens?", The Lancet, (1971), p. 1304.
R. A. Kahn et al., "Alternative Source and Substitutes for Therapeutic Blood Sources", Blood, Journal of the American Society of Hematology, vol. 66-1, (Jul., 1985), pp. 1-12.
C. Tabor, Tabor's Cyclopedic Medical Dictionary, (Philadelphia, Pa., F. A. Davis Co., 1977), pp. H21-22.
Merck Manual, 14th ed., (Rahway, N.J.: Merck & Co., Inc.), 1982.
"Blood", Van Nostrand's Scientific Encyclopedia, 1968, pp. 214-215.
Documenta Geigy, (Basel, Switzerland: J. R. Geigy, 1956).
Geigy Scientific Tables, 8th ed., (Basel, Switzerland: Ciba-Geigy, Ltd., 1982).
Department of Defense, Document No. 84-R-0033, p. 7.
Ostra, Liposomes, (New York: Marcelle-Deeker, 1980).
R. Bucala et al., "Cytotoxicity of a Perfluorocarbon Blood Substitute to Macrophages in Virto", Science, vol. 220, (May, 1983), pp. 965-967.
P. Lundsgaard-Hansen, M.D. and B. Tschirren, M.D., "Modified Fluid Gelatin as a Plasma Substitute", Blood Substitutes and Plasma Expanders, (New York: Alan R. Liss, 1978), p. 227.
Ashwood-Smith, M. S., "Polyvinyl-Pyrolidone Solutions Used in Plasma Expander Potential Carcinogens"; Lancet, 1, (1971), p. 1304.
Towers, R. P., "Lymph Node Changes Due to Polyvinyl-Pyrolidone", Journal of Clinical Pathology 10, (1975-1977), p. 1957, BF1400.A1J83.
F. DeVenuto et al., "Preparation and Evaluation of Pyridoxalated Polymerized Human Hemoglobin", Journal of Surgical Research, vol. 34, pp. 205-212, (1983).

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