Substitute for human blood and a method of making the same

Details Substitute for human blood and a method of making the same Substitute for human blood and a method of making the same

1988-04-15

1989-08-01

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, A61K 3700

Patent

active

048533700

ABSTRACT:
The method of this invention yields a two phase liquid aqueous system which replicates the two phase heterogeneous physico-chemical system of naturally securing whole human blood. The method produces: (1) a composition of matter which comprises an oxygen transport solution; (2) when pyridoxalated-polymerized hemoglobin and other specific additives are incorporated, said composition comprises a synthetic blood useful as a physiological substitute for human blood; and (3) when said blood substitute is processed further, yields a microencapsulated composition with time released characteristics that can transport oxygen. The invention overcomes the obstacles that have prevented the use of pyridoxalated-polymerized hemoglobin and other forms of modified hemoglobin in the preparation of oxygen transport solutions.

REFERENCES:
patent: 4133874 (1979-01-01), Miller et al.
patent: 4252793 (1981-02-01), Altman
patent: 4321259 (1982-03-01), Nicolau et al.
patent: 4343797 (1982-08-01), Ecanow et al.
patent: 4439424 (1984-03-01), Ecanow et al.
patent: 4539204 (1985-09-01), Ecanow et al.
patent: 4547490 (1985-10-01), Ecanow et al.
patent: 4558032 (1985-12-01), Ecanow et al.
patent: 4596788 (1986-06-01), Ecanow et al.
patent: 4738852 (1988-04-01), Ecanow et al.
F. DeVenuto et al., "Preparation and Evaluation of Pyridoxalated Polymerized Human Hemoglobin", Journal of Surgical Research, vol. 34, pp. 205-212 (1983).

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