Substantially purified tumor growth inhibitory factor

Details Substantially purified tumor growth inhibitory factor Substantially purified tumor growth inhibitory factor

1984-04-20

1987-11-24

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 32, 435 68, 435948, 530300, 530350, 530399, 530828, 424 85, A61K 3700, C07K 1500, C12Q 118, C12P 2100

Patent

active

047089482

ABSTRACT:
A substantially purified substance having the property of inhibiting tumor cell growth without inhibiting the growth of normal human cells and without having antiviral effect, further having the properties of: (a) ranging from about 3,500 to 45,000 daltons in molecular weight; (b) being heat stable at about 56.degree. C. when exposed for about 30 minutes; (c) possessing isoelectric point ranging from pI 4-8; and (d) eluting on high pressure liquid chromatography at about 10-35% of 2-propanol or about 25-50% of acetonitrile gradient, has been disclosed. The substance has utility as an antitumor or antineoplastic agent. The substance may also be useful as an index or tumorgenic activity in an organism. The mitogenic and growth stimulatory activity possessed by the substance of the present invention may be useful in wound healing and treating burn-victims.

REFERENCES:
patent: 4261976 (1981-04-01), Isselbacher
Matthews, N. et al., Br. J. Cancer, 42(3):416-422(1980).
Funkhouser, W. K. et al., Surg. Forum, 35:394-396(1984).
Dittmer, John E., "Suppression of Tumor Cell Growth in vitro by a Bone Marrow Factor", Cancer Research, vol. 44, (Mar. 1984) pp. 900-903.
Immunology, vol. 44, No. 1, (Sep. 1981) pp. 135-142, "Production of an Anti-Tumor Cytotoxin by Human Monocytes", Matthews et al.
Todaro, et al.; Tumor Cell Heterogeneity; 1982; pp. 205-224, vol. 4.
Todaro, et al., "Transforming Growth Factors Produced by Certain Human Tumor Cells; Polypeptides, P.N.A.S.", Sep. 1980; pp. 5258-5262; vol. 77.
Holley, et al.; Activity of Kidney Epithelial Cell Growth Inhibitor on Lung and Mammary Cells; Feb. 1983; pp. 141-147; vol. 7, Cell Biol.
Holley et al.; Preparation and Properties of a Growth Inhibitor Produced by Kidney Epithelial Cells; Jul. 1983; pp. 525-526; vol. 7, Cell Biol.
McMahon et al.; "Purification & Properties of a Rat Liver Protein that Specifically Inhibits Proliferation . . . " P.N.A.S. Jan. 82; vol. 79, pp. 456-460.
Savage et al.,; Epidermal Growth Factor and a New Derivative; 1972; pp. 7609-7611; vol. 247, J. Biological Chemistry.
Greenwood et al., The Preparation of 131-I-Labelled Human Growth Hormone of High Specific Radioactivity, Biochem J., pp. 114-123, vol. 89 (1963).
De Larco et al., Sarcoma Growth Factor from Mouse Sarcoma Virus Transformed Cells, pp. 3685-3690, vol. 255, (1980) J. Biol. Chem.
Holley et al., Purification of Kidney Epithelial Cell Growth Inhibitors, pp. 5989-5992, vol. 77, (1980), Proc. Natl. Acad. Sci.
Iwata et al., Isolation and Characterization of Human Tumor Cell Inhibitory Factors, (1983), Fed. Proc.
Iwata et al., Methods for Rapid Microanalysis of Transforming Factors (TGFs) NAD Cell Inhibitory Factors, (1982), J. Cell. Biochem.

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