Substantially pure zonulin, a physiological modulator of mammali

Details Substantially pure zonulin, a physiological modulator of mammali Substantially pure zonulin, a physiological modulator of mammali

1997-05-21

1999-08-31

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530839, 530844, 514 2, 514 12, 514 21, C07K 1400, C07K 14435, A61K 3816, A61K 3817

Patent

active

059455101

ABSTRACT:
A substantially pure mammalian protein, hereinafter "zonulin", that is a physiological modulator of mammalian tight junctions is disclosed, as well as methods for the use of the same.

REFERENCES:
Uzzau et al, "Purification and Preliminary Molecular Characterization of Vibrio cholerae Zonula Occludens Toxin", 96th ASM General Meeting, Abstract No. B-204, p. 190 (May 19-23, 1996).
Fasano et al, "The Enterotoxin Effect of Zonula Occludens Toxin on Rabbit Small Intestine Involves the Paracellular Pathway", Gastroenterology, 112:839-846 (1997).
Fasano et al, "Modulation of Intestinal Tight Junctions by Zonula Occludens Toxin Permits Enteral Administration of Insulin and Other Macromolecules in an Animal Model", Rapid Publication, J. Clin. Invest., 99(6):1158-1164 (1997).
Baudry et al, "Cloning of a Gene (zot) Encoding a New Toxin Produced by Vibrio cholerae" Infection and Immunity, 60(2):428-434 (1992).

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