Substantially pure rheumatoid arthritis specific protein and an

Details Substantially pure rheumatoid arthritis specific protein and an Substantially pure rheumatoid arthritis specific protein and an

1985-09-13

1988-05-03

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530387, C07K 1500

Patent

active

047421576

ABSTRACT:
A substantially pure rheumatoid arthritis specific protein (RASP) and an antibody against the rheumatoid arthritis specific protein (anti-RASP antibody) are disclosed. The RASP is found specifically in the serum or plasma of a patient suffering from rheumatoid arthritis, and may be detected using an anti-RASP antibody easily and effectively. Therefore, the anti-RASP antibody of the present invention is useful for the diagnosis of rheumatoid arthritis by the criterion of the presence of RASP.

REFERENCES:
Biol. Abstr. vol. 86, 159118.
T. Kanamono et al, "An Experience of Plasma Exchange for Patients with Rheumatoid Arthritis", pp. 280-286 (Ref. 1).
T. Kanamono et al, "Analysis of Plasma Filtrated Protein and Finding of New Rheumatoid Arthritis Specific Protein", p. 20 (Ref. 2).
O. Oda et al, "Seikagaku (Biochemistry)", vol. 55, No. 8, p. 767 (1983), (Ref. 3).
H. Yamaga et al, "Abnormal Plasma Protein in the Patients with Rheumatoid Arthritis", Jun. 22-24, 1984 (Ref. 4).

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