Substantially pure receptor like TGF-.beta. 1 binding molecules

Details Substantially pure receptor like TGF-.beta. 1 binding molecules Substantially pure receptor like TGF-.beta. 1 binding molecules

1991-06-18

1993-07-20

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

436503, 530395, C07K 1508, G01N 33567

Patent

active

052294951

ABSTRACT:
The invention relates to a family of substantially pure, receptor like TGF-.beta.1 binding glycoproteins. These molecules are characterized by molecular masses of 160 kd, 70-80 kd, and 30-40 kd as determined by SDS-PAGE, and the ability to bind the TGF-.beta.1 molecule. This family of molecules is useful in identifying and/or quantifying TGF-.beta.1 in a sample, as well as inhibiting its effect on cells.

REFERENCES:
Miyazono et al., Nature 338 (6211): 158-160 (Mar. 9, 1989).
Miyazono et al., J. Biol. Chem. 263 (13): 6407-6415 (1988).
Kanzaki et al., Cell 61: 1051-1061 (Jun. 15, 1990).
Wakefield et al., J. Biol. Chem. 263(16); 7646-7654 (1988).

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