Substantially pure interleukin-9 receptor and uses thereof

Details Substantially pure interleukin-9 receptor and uses thereof Substantially pure interleukin-9 receptor and uses thereof

1990-09-19

1992-05-26

Russell, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Glycoprotein, e.g., mucins, proteoglycans, etc.

530351, C07K 302, C07K 1506, C07K 1514

Patent

active

051169517

ABSTRACT:
The invention relates to substantially pure interleukin 9 receptor molecules and the use thereof. The uses include use as an interleukin-9 inhibitor, as a diagnostic agent for determining interleukin-9, and as a screening agent for pharmaceuticals. The interleukin-9 receptor is characterized as a glycoprotein of about 94 kilodaltons which, upon digestion with N-glycosidase F, yields a peptide of about 54 kilodaltons.

REFERENCES:
patent: 4578335 (1986-03-01), Urdal et al.
"The Murine Interleukin-4 Receptor: Molecular Cloning and Characterization of Secreted and Membrane Bound Forms", Mosley et al., Cell, vol. 59, Oct. 20, 1989, pp. 335-348.
Gillis, "T-Cell-Derived Lymphokines", from Fundamental Immunology, 2nd ed., Paul, ed. Raven Press Ltd. 1989, pp. 621, 632, 634, 635.
Uyttenhove et al., Proc. Natl. Acad. Sci. 85: 6934-6938 (Sep. 1988).
Van Snick et al., J. Exp. Med. 169: 363-368 (Jan., 1989).
Yang et al., Blood 74(6): 1880-1884 (Nov. 1, 1989).
Fanslow et al., Science 248: 739-742 (May 11, 1990).
Renauld et al., Cytokine 2(1): 9-12 (Jan., 1990).
Renauld et al., J. Immunol. 144: 4235-4241 (Jun. 11, 1990).
Druez et al., J. Immunol. 145: 2494-2499 (Oct. 15, 1990).

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