Substantially pure histidine-linked protein polymer conjugates

Details Substantially pure histidine-linked protein polymer conjugates Substantially pure histidine-linked protein polymer conjugates

1997-12-19

1999-11-16

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 424 857, 435188, 514 2, 530345, 530351, 530409, 530410, A61K 3820, A61K 3821, A61K 3802, C07K 1113

Patent

active

059852631

ABSTRACT:
Substantially pure histidine-linked protein-polymer conjugates and processes for their preparation are disclosed. The processes include contacting a protein with an activated polymer under conditions sufficient to facilitate covalent attachment of at least a portion of the polymer strands on histidine residues of the protein and thereafter substantially separating the histidine-linked conjugates from the remaining reactants.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4609546 (1986-09-01), Hiratani
patent: 4766106 (1988-08-01), Katre et al.
patent: 4810638 (1989-03-01), Albarella et al.
patent: 4894226 (1990-01-01), Aldwin et al.
patent: 4897471 (1990-01-01), Stabinsky
patent: 4917888 (1990-04-01), Katre et al.
patent: 5004605 (1991-04-01), Hershenson et al.
patent: 5109120 (1992-04-01), Ueno et al.
patent: 5122614 (1992-06-01), Zalipsky
patent: 5281698 (1994-01-01), Nitecki
patent: 5382657 (1995-01-01), Karasiewicz et al.
patent: 5468478 (1995-11-01), Saifer et al.
patent: 5539063 (1996-07-01), Hakimi et al.
patent: 5559213 (1996-09-01), Hakimi et al.
patent: 5646242 (1997-07-01), Baker et al.
patent: 5650234 (1997-07-01), Dolence et al.
patent: 5676942 (1997-10-01), Testa et al.
patent: 5711944 (1998-01-01), Gilbert et al.
patent: 5738846 (1998-04-01), Greenwald et al.
patent: 5747646 (1998-05-01), Hakimi et al.
Gotoh, Y., et al. Chemical Modification of Silk Fibroin with Cyanuric Chloride-Activated Poly(ethylene glycol): Analysis of Reaction by H-NMR Spectroscop and . . . , Bioconjugate Chem, vol. 4; pp. 554-559; 1993.
Lundblad, R.L., et al. Chemical Reagents for Protein Modification, CRC Press, Inc., vol 1; pp. 105-125; 1988.
Shearwater Polymers, Inc. Catalog, p. 45; Jan. 1996.
Goeddel, D.V. et al., The Structure of Eight Distinct Cloned Human Leukocyte Interferon cDNAs Nature, vol. 290; pp. 20-26; Mar. 5, 1981.
Zalipsky, S. et al., Attachment of Drugs to Polyethylene Glycols Eur. Polym. J., vol. 19, No. 12; pp. 1177-1183; 1983.
Zalipsky S. et al., Evaluation of a New Reagent for Covalent Attachment of Polyethylene Glycol to Proteins Biotechnology and Applied Biochemistry, vol. 15; pp. 100-114; 1992.
Konstek, P., HumanType I Interferons: Structure and Function, Acta Virologica, vol. 38; pp. 345-360; 1994.
Kinstler, O.B. et al., Characterization and Stability of N-terminally PEGylated rhG-CSF, Pharmaceutical Res., vol. 13, No. 7; pp. 996-1002; 1996.
Monkarsh, S.P. et al., Positional Isomers of Monopegylated Interferon alpha-2a: Isolation, Characterization, and Biological Activity, Analytical Biochemistry, vol. 247; pp. 434-440; 1997.
Viscomi, G.C., Structure-activity of Type I Interferons, Biotherapy, vol. 10; pp. 59-86; 1997.
Borokhov et al. Chemical Modification of the Recombinant . . . Biochem. Biophys. Res. Comm. vol. 167, No. 1, pp. 74-80, Feb. 28, 1990.

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