Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1986-05-05
1988-11-15
Brown, Johnnie R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 530827, 435 68, 435948, 43524031, 424 854, 424 851, C07K 1500, C12N 500
Patent
active
047850779
ABSTRACT:
A new, human proteinaceous lymphokine denominated cytotoxicity triggering factor (CTF) is disclosed as are methods of its preparation and use. Substantially pure CTF has an apparent M.sub.r of about 55 kd, is capable of inducing secretion of a tumor-killing factor containing tumor necrosis factor-alpha from primed monocytes, and is substantially free from pyrogen as well as interferon-gamma, interleukin-2 and direct cytotoxin.
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Edgington Thomas S.
Gregory Susan A.
Kornbluth Richard
Brown Johnnie R.
Draper Garnette D.
Scripps Clinic and Research Foundation
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