Substantially cell membrane impermeable compound and use...

Details Substantially cell membrane impermeable compound and use... Substantially cell membrane impermeable compound and use...

2006-07-11

2006-07-11

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S018700, C514S008100, C530S331000, C530S332000

Reexamination Certificate

active

07074766

ABSTRACT:
The present invention relates to a compound according to Formula (I): A-(L-Y)p, wherein A comprises at least one substantially cell-membrane impermeable pendant group; L comprises any suitable linker and/or spacer group; Y comprises at least one arsenoxide or arsenoxide equivalent; p is an integer from 1 to 10; and the sum total of carbon atoms in A and L together, is greater than 6.

REFERENCES:
patent: 2951766 (1960-09-01), White
patent: 3883650 (1975-05-01), Friedheim et al.
patent: 5281588 (1994-01-01), Maes et al.
patent: 5459263 (1995-10-01), Floc'H et al.
patent: 9851297 (1999-11-01), None
patent: 9955344 (1999-11-01), None
J. Rudinger. In: Peptide Hormones, JA Parsons, Ed. (1976) 1-7.
D. Voet and J.G. Voet. Biochemistry, 2nd Edition.(1995), pp. 235-241.
D.E. Smilek, et al. Proc. Natl. Acad. Sci. USA (1991) 88, pp. 9633-9637.
Fairlamb, et al. “Trypanothione is the Primary Target for Arsenical Drugs against African Trypanosomes”Proc. Natl. Acad. Sci., vol. 26, pp. 2607-2611 (1989).
Fairlamb, A., “Metabolism and Functions of Trypamothione in the Kenetoplastida”,Ann. Rev. Microbiol., vol. 46, pp. 695-729 (1992).
Cunningham, et al. “Mechanism of Inhibition of Trypanothione Reductase and Glutathione Reductase by Trivalent Organic Arsenicals”Eur. J. Biochem., vol. 221, pp. 285-295 (1994).
Bhargava, et al. “Effect of arsenical Drugs on Glutathione Metabolism ofLitomosoides carinii” Mol. Biochem. Parasitol, vol. 9, 99 29-35 (1983).
Carter, et al. “Arsenical-resistant Trypanosomes Lack an Unusual Adenosine Transporter”Nature, vol. 36, No. 6408, pp. 173-176 (1993).
Pisciotto, P., et al. “Induction of Mucosal Glutathione Synthesis by Arsenic”Biochimica et Biophysica Acta, vol. 628, pp. 241-243 (1980).
Chemical Abstracts Registry No. 1112-90-3. p-amino phenyl arsenoxide.
Chemical Abstracts Registry No. 637-03-6. Arsenosobenzene.
Beilstein Registry No. 21688, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 22377, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 51552, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 111664, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 116874, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 273946, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 358898, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3126376, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3129248, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3135458, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3141604, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3152231, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3233826, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3235693, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3254079, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3273842, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3275319, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3285106, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3293148, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3296676, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3298747, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3319010, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3341328, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3344707, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Beilstein Registry No. 3531489, 1988-2003 Beilstein Institut zur Foerderung der Chemischen Wissenschaften.
Happersberger, (1998)Eur. Mass Spectrom—4:209-214.

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