Substantially anhydrous crystalline cefadroxil and method for pr

Details Substantially anhydrous crystalline cefadroxil and method for pr Substantially anhydrous crystalline cefadroxil and method for pr

1992-01-27

1994-07-12

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540228, 540215, A61K 31545, C07D50122

Patent

active

053290011

ABSTRACT:
The invention relates to a substantially anhydrous crystalline cefadroxil having a water content between about 0.8% and 3.9%.
Such cefadroxil is obtained slurrying a cefadroxil solvate of dimethylacetamide, or of N-methyl-2-pyrrolidone or of monomethylformamide, with isopropyl alcohol with up to 4% of water and preferably in the presence of methanol in an amount lower than 60%, at a temperature of about +45.degree. C. to +55.degree. C. and then filtering the so obtained compound.

REFERENCES:
patent: 4504657 (1985-03-01), Bouzard
patent: 4624948 (1986-11-01), Dunkheim et al.
patent: 4668782 (1987-05-01), Ichikawa et al.
Pfeiffer et al., Jour. of Pharmaceutical Sciences vol. 59 No. 12 (1970) pp. 1809-1814.

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